Background：This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha（IIb） subunits. These subunits play a crucial role in the integrin alpha（IIb）beta（3） inside-out signaling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.
仕様
Synonyms：AA589454,Ancient ubiquitous protein 1,AUP 1,aup1,AUP1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Recombinant protein of human AUP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：50-1：200
Swissprot：Q9Y679
Isotype：IgG
Research Areas：Cell Biology, Cardiovascular, Metabolism
