Background：The protein encoded by this gene is a member of the ADAM （a disintegrin and metalloproteinase） protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
仕様
Synonyms：A disintegrin and metalloproteinase domain 15 （metargidin）,A disintegrin and metalloproteinase domain 15,ADA15,ADAM 15,ADAM metallopeptidase domain 15,Adam15,and cysteine-rich protein 15,Disintegrin and metalloproteinase domain-containing protein 15,disintegrin-like,EC 3.4.24.,MDC 15,MDC-15,MDC15,Metalloprotease RGD disintegrin protein,Metalloproteinase like disintegrin like and cysteine rich protein 15,Metalloproteinase-like,Metargidin
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human ADAM15
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q13444
Isotype：IgG
Research Areas：Cancer, Cell Biology, Signal transduction
