Background：This gene encodes a member of the bone morphogenetic protein （BMP） receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine （threonine） kinase receptors： type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
仕様
Synonyms：BMP type II receptor,BMP type-2 receptor,BMPR 2,BMPR 3,BMPR II,BMPR-2,BMPR-II,Bmpr2,BMPR2,BMPR3,BMPRII,BMR 2,BMR2,Bone morphogenetic protein receptor type 2,Bone morphogenetic protein receptor type II,Bone morphogenetic protein receptor type-2,Bone morphogenic protein receptor type II serine threonine kinase,BRK 3,BRK3,PPH 1,PPH1,Serine threonine kinase type II activin receptor like kinase,T ALK,TALK,Type II activin receptor like kinase
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.2mg/mL
Immunogen：Recombinant protein of human BMPR2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q13873
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Signal transduction, Stem cells
