Background：This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.
仕様
Synonyms：R1,Ribonucleoside diphosphate reductase large subunit,Ribonucleoside diphosphate reductase M1 chain,Ribonucleoside diphosphate reductase subunit M1,Ribonucleoside reductase,large subunit,Ribonucleoside-diphosphate reductase large subunit,Ribonucleoside-diphosphate reductase subunit M1,Ribonucleotide reductase large chain,Ribonucleotide reductase large subunit,Ribonucleotide reductase M1,Ribonucleotide reductase M1 polypeptide,Ribonucleotide reductase R1 subunit,Ribonucleotide reductase,M1 subunit,RIR 1,RIR1,RIR1,RR 1,RR1,RRM 1,RRM1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human RRM1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000
Swissprot：P23921
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
