Background：Human NAIF1 is located on chromosome 9q34.11 and encodes 327 amino acids with a homeodomain-like region and two nuclear localization signals at its N-terminal region. NAIF1 is conserved across diverse species, including human, mouse, crab-eating macaque, dog, chicken and frog, and shares no obvious homology to any known genes or proteins. NAIF1 was predominantly localized in the nucleus. Overexpression of NAIF1 inhibited cell growth and induced apoptosis. Furthermore, NAIF1 transfection caused both decreases in mitochondrial membrane potential and caspase-3 activation. In summary, NAIF1 is a nuclear protein that induces apoptosis when overexpressed.
仕様
Synonyms：bA379C10.2,C9orf90,chromosome 9 open reading frame 90,Naif1,NAIF1,Nuclear apoptosis-inducing factor 1,RP11-379C10.2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：1.2mg/mL
Immunogen：Recombinant protein of human NAIF1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：50-1：200
Swissprot：Q69YI7
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
