Background：The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein （MAP） kinase superfamily （MAPK/ERK, SAPK/JNK, p38）, which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
仕様
Synonyms：Dual specificity phosphatase 4,Dual specificity protein phosphatase 4,Dual specificity protein phosphatase hVH2,DUS4,DUSP 4,Dusp4,HVH 2,HVH2,MAP kinase phosphatase 2,Mitogen activated protein kinase phosphatase 2,Mitogen-activated protein kinase phosphatase 2,MKP 2,MKP-2,MKP2,Serine/threonine specific protein phosphatase,TYP,Typ1,VH 2,VH1 homologous phosphatase 2,VH2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Recombinant protein of human DUSP4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：50-1：150
Swissprot：Q13115
Isotype：IgG
Research Areas：Cancer, Cell Biology, Signal transduction
