Background：Mitogen-activated protein （MAP） kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases （DSPs） are a subclass of the protein tyrosine phosphatase （PTP） gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.
仕様
Synonyms：Dual specificity protein phosphatase 22,DUS22,Dusp22,JNK stimulatory phosphatase 1,JNK-stimulatory phosphatase-1,JSP 1,JSP-1,JSP1,LMW DSP2,LMW-DSP2,Low molecular weight dual specificity phosphatase 2,MAP kinase phosphatase x,Mitogen activated protein kinase phosphatase x,Mitogen-activated protein kinase phosphatase x,MKP-x,MKPX
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human DUSP22
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
