Background：Apurinic/apyrimidinic （AP） sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
仕様
Synonyms：AP endonuclease 1,AP endonuclease class I,AP lyase,APE 1,APE,APE-1,APEN,APEX 1,APEX,APEX nuclease （multifunctional DNA repair enzyme） 1,Apex nuclease 1,APEX nuclease,APEX1,APEX1,Apurinic endonuclease,Apurinic-apyrimidinic endonuclease 1,Apurinic/apyrimidinic （abasic） endonuclease,Apurinic/apyrimidinic endonuclease 1,Apurinic/apyrimidinic exonuclease,APX,BAP1,Deoxyribonuclease （apurinic or apyrimidinic）,DNA （apurinic or apyrimidinic site） lyase,DNA-（apurinic or apyrimidinic site） lyase,mitochondrial,EC 4.2.99.18,HAP 1,HAP1,Human Apurinic endonuclease 1,MGC139790,Multifunctional DNA repair enzyme,Redox factor 1,Redox factor-1,REF 1,REF 1 protein,REF-1,REF1,REF1 protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：0.2mg/mL
Immunogen：Recombinant protein of human APEX1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000
Swissprot：P27695
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling
