Background：May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.IkappaBNS, the nuclear IkappaB-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.IkappaBNS has been identified as a member of the IkappaB family of NF-kappaB inhibitors, which undergoes induction upon TCR signaling. IkappaBNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine.
仕様
Synonyms：I-kappa-B-delta,IkappaBdelta,IkappaBNS,IkB-delta,IKBD,IKBNS,NF-kappa-B inhibitor delta,NFKBID,Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor delta,T-cell activation NFKB-like protein,TA-NFKBH
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human NFKBID
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000, IHC 1：25-1：100
Swissprot：Q8NI38
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Immunology, Signal transduction
