Background：This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
仕様
Synonyms：I kappa B alpha,I-kappa-B-alpha,IkappaBalpha,IkB-alpha,IKBA,IKBA,IKBalpha,MAD 3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF kappa B inhibitor alpha,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,Nuclear factor of kappa light chain gene enhancer in B cells,Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：0.1mg/mL
Immunogen：Recombinant protein of human NFKBIA
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000
Swissprot：P25963
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
