Background：Cytochrome c oxidase （COX）, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A：farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine （N204K）, is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A （Charcot-Marie-Tooth type 1A） duplication and with HNPP （hereditary neuropathy with liability to pressure palsies） deletion.
仕様
Synonyms：2410004F01Rik,AU042636,COX10,COX10,Cytochrome c oxidase assembly protein,Cytochrome c oxidase subunit X,Heme A farnesyltransferase,Heme O synthase,OTTMUSP00000006085,Protoheme IX farnesyltransferase,mitochondrial,Protoheme IX farnesyltransferase,mitochondrial precursor,RP23-78H18.1
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human COX10
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q12887
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
