Background：The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 （MED12）, along witHuman, MouseED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.
仕様
Synonyms：Activator recruited cofactor 240 kDa component,Activator-recruited cofactor 240 kDa component,ARC240,CAG repeat protein 45,CAGH45,HOPA,KIAA0192,MED12,MED12,Mediator complex subunit 12,Mediator of RNA polymerase II transcription subunit 12,OPA containing protein,OPA-containing protein,Thyroid hormone receptor associated protein complex 230 kDa component,Thyroid hormone receptor-associated protein complex 230 kDa component,TNRC11,Trap230,Trinucleotide repeat containing gene 11 protein,Trinucleotide repeat-containing gene 11 protein
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human MED12
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q93074
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
