Background：This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 （HIF-1）, which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
仕様
Synonyms：ARNT interacting protein,ARNT-interacting protein,Basic helix loop helix PAS protein MOP1,Basic-helix-loop-helix-PAS protein MOP1,bHLHe78,Class E basic helix-loop-helix protein 78,HIF 1A,HIF 1alpha,HIF-1-alpha,HIF1 A,HIF1 Alpha,HIF1,HIF1-alpha,HIF1A,HIF1A,Hypoxia inducible factor 1 alpha,Hypoxia inducible factor 1 alpha isoform I.3,Hypoxia inducible factor 1 alpha subunit,Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor,Hypoxia inducible factor 1,alpha subunit （basic helix loop helix transcription factor）,Hypoxia inducible factor1alpha,Hypoxia-inducible factor 1-alpha,Member of PAS protein 1,Member of PAS superfamily 1,Member of the PAS Superfamily 1,MOP 1,MOP1,PAS domain-containing protein 8,PASD 8,PASD8
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：0.2mg/mL
Immunogen：Synthetic peptide of human HIF1A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000
Swissprot：Q16665
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism
