Background：TP53INP1 （tumor protein p53-inducible nuclear protein 1）, also known as p53DINP1, SIP or Teap, is a 240 amino acid protein that localizes to nuclear bodies and exists as two alternatively spliced isoforms, designated p53DINP1a and p53DINP1b. Expressed ubiquitously with higher expression in testis, pancreas and spleen tissue, TP53INP1 functions in response to double-stranded DNA breaks and regulates p53-mediated apoptosis, specifically by phosphorylating human p53 at Ser 46, an event that leads to cell death. Additionally, TP53INP1 is thought to interact with p73 and may be involved in the regulation of p73-controlled cell cycle progression. TP53INP1 expression is downregulated in pancreatic ductal adenocarcinomas, suggesting that, via its ability to induce cell death, TP53INP1 plays a role in tumor suppression.
仕様
Synonyms：DKFZp434M1317,FLJ22139,p53 damage inducible nuclear protein 1,p53 dependent damage inducible nuclear protein 1,p53 inducible nuclear protein 1,p53 inducible p53DINP1,p53-dependent damage-inducible nuclear protein 1,p53DINP1,SIP,Stress induced protein,Stress-induced protein,T53I1,Teap,TP53 DINP1,TP53 INP1,TP53DINP1,TP53INP1,TP53INP1A,TP53INP1B,Tumor protein p53 inducible nuclear protein 1,Tumor protein p53-inducible nuclear protein 1
Host：Rabbit
Reactivity：Human
Applications：WB,IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human TP53INP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
