Background：There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure.
仕様
Synonyms：EC 2.7.1.37,LIM domain containing protein kinase,LIM domain kinase 1,LIM kinase,LIM motif containing protein kinase,LIMK 1,LIMK,LIMK-1,limk1,LIMK1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.9mg/mL
Immunogen：Synthetic peptide of human LIMK1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：P53667
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal transduction
