Background：PLU-1 is a large （1,544 amino acid） nuclear protein that interacts with brain factor-1 （BF-1） and paired box 9 （PAX9）, both of which are developmental transcription factors. PLU-1 belongs to the testis-cancer antigen group of proteins and is a member of the ARID family of DNA binding proteins. It is a multi-domain protein with strong transcriptional repression properties. PLU-1 shows restricted expression in adult tissues, with high expression in testis and transient expression in the pregnant mammary gland. Both the PLU-1 gene and the PLU-1 protein product are specifically upregulated in breast cancer. PLU-1 may be important in meiotic transcription because of its apparent association with chromatin.
仕様
Synonyms：Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,JARID1B,Jumonji AT rich interactive domain 1B,Jumonji/ARID domain-containing protein 1B,Kdm5b,KDM5B,Lysine （K） specific demethylase 5B,Lysine demethylase 5B,Lysine specific demethylase 5B,Lysine-specific demethylase 5B,PLU-1,PLU1,PPP1R98,Protein phosphatase 1 regulatory subunit 98,PUT1,putative DNA/chromatin binding motif,RBBP2H1A,RBP2 like,RBP2-H1,Retinoblastoma-binding protein 2 homolog 1,Retinoblastoma-binding protein 2 homolog 1A
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：1.5mg/mL
Immunogen：Synthetic peptide of human KDM5B
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q9UGL1
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
