Background：This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase （Mapk8）. This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 （MEKK1） induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor （REST） is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
仕様
Synonyms：C jun amino terminal kinase interacting protein 1,C-jun-amino-terminal kinase-interacting protein 1,IB 1,IB-1,IB1,Islet brain 1,Islet-brain 1,JIP 1,JIP-1,JIP1,JNK interacting protein 1,JNK MAP kinase scaffold protein 1,JNK-interacting protein 1,MAPK8IP 1,MAPK8IP1,MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1,Mitogen activated protein kinase 8 interacting protein 1,Mitogen-activated protein kinase 8-interacting protein 1,PRKM8,PRKM8 interacting protein,PRKM8IP
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human MAPK8IP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
