Background：The protein encoded by this gene belongs to the IRF （interferon regulatory factor） family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor （TLR） signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t（6;14）（p25;q32）, may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
