Background：The protein encoded by this gene is a member of the protein tyrosine phosphatase （PTP） family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains： a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
仕様
Synonyms：APO1/CD95 （Fas） associated phosphatase,DKFZp686J1497,FAP 1,FAP1,Fas associated phosphatase 1,Fas associated protein tyrosine phosphatase 1,HGNC：9646,hPTPE1,Phosphatase rip,PNP 1,PNP1,Protein tyrosine phosphatase 1 Fas associated,protein tyrosine phosphatase 1E,Protein tyrosine phosphatase non receptor type 13,Protein tyrosine phosphatase nonreceptor type 13,Protein tyrosine phosphatase PTPL1,protein tyrosine phosphatase,non-receptor type 13 （APO-1/CD95 （Fas）-associated phosphatase）,PTP BAS,PTP BL,PTP E1,PTP1E,PTPL 1,PTPL1,PTPLE,PTPN 13,PTPN13,Tyrosine protein phosphatase non receptor type 13
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human PTPN13
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q12923
Isotype：IgG
Research Areas：Cancer, Cell Biology, Signal transduction
