Background：Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.
仕様
Synonyms：Caspase like protein ESPL1,Caspase-like protein ESPL1,ESP 1,ESP1,ESPL 1,Espl1,ESPL1,Extra spindle poles like 1,Extra spindle poles like 1 protein,Extra spindle poles-like 1 protein,FLJ46492,KIAA0165,Separase,Separin,Similar to fission yeast cut1and gene,SSE
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human ESPL1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000, IHC 1：25-1：100
Swissprot：Q14674
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
