Background：The accumulation of unfolded proteins within the endoplasmic recticulum （ER） of yeast and mammalian cells activates the unfolded protein response （UPR） pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p （for inositol-requiring and ER-to-nucleus signaling protein）. IRE1a and IRE1b are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
仕様
Synonyms：IRE1b,IRE1-BETA
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human ERN2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
