Background：The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine （T4） by outer ring deiodination （ORD） to bioactive 3,3',5-triiodothyronine （T3）. It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine （Sec） residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence （SECIS）, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
仕様
Synonyms：5DII,D2,Deiodinase,iodothyronine,type II,DIO2,DIOII,EC 1.97.1.10,IOD2,ITDI2,SelY,Thyroxine deiodinase,type II,TXDI2,Type 2 DI,Type 2 iodothyronine deiodinase,Type II 5' deiodinase,Type II iodothyronine deiodinase,Type-II 5''-deiodinase
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.9mg/mL
Immunogen：Synthetic peptide of human DIO2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q92813
Isotype：IgG
Research Areas：Cancer, Metabolism, Neuroscience, Signal transduction
