Background：The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11.
仕様
Synonyms：ARVD11,Cadherin family member 2,CDHF2,Desmocollin 3,Desmocollin-2,Desmocollin-3,Desmocollin2,Desmosomal glycoprotein II and III,Desmosomal glycoprotein II,Desmosomal glycoprotein II/III,Desmosomal glycoprotein III,DG2,DGII/III,DKFZp686I11137,DSC 2,DSC2,DSC2,DSC3
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.7mg/mL
Immunogen：Synthetic peptide of human DSC2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q02487
Isotype：IgG
Research Areas：Cardiovascular, Signal transduction
