Background：This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.
仕様
Synonyms：AH antigen,Cell cycle dependent 350K nuclear protein,CENF,CENP F,CENP F kinetochore protein,CENP-F,CENPF,CENPF kinetochore protein,CENPF,Centromere protein F 350/400ka,Centromere protein F,Centromere protein F,350/400kDa,CILD31,Hcp 1,Hcp1,Kinetochore protein CENP F,Kinetochore protein CENPF,Mitosin,PRO1779,STROMS
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.2mg/mL
Immunogen：Synthetic peptide of human CENPF
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：P49454
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
