Background：This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1：1：1：1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.
仕様
Synonyms： alpha-1 polypeptide,cardiac muscle,isoform 1,L type,CAC1C,CACH 2,CACH2,CACN 2,CACN2,CACNA1C,CACNL1A1,Calcium channel,Calcium channel cardic dihydropyridine sensitive alpha 1 subunit,Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle,Calcium channel voltage dependent L type alpha 1C subunit,CaV1.2,CCHL1A1,DHPR alpha 1,DHPR alpha 1 subunit,LQT8,TS,Voltage dependent L type calcium channel alpha 1C subunit,Voltage dependent L type calcium channel subunit alpha 1C,Voltage gated calcium channel alpha subunit Cav1.2,Voltage gated calcium channel subunit alpha Cav1.2,Voltage gated L type calcium channel Cav1.2 alpha 1 subunit,splice variant 10*,Voltage-dependent L-type calcium channel subunit alpha-1C,Voltage-gated calcium channel subunit alpha Cav1.2
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Synthetic peptide of human CACNA1C
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q13936
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
