Background：The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon （IFN）, this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 （ISGF3G）, in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP （EP300/CREBBP） has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：Homo sapiens interferon alpha induced transcriptional activator,interferon alpha induced transcriptional activator,ISGF 3,ISGF3,MGC59816,P113,signal transducer and activator of transcription 2 113kD,Signal transducer and activator of transcription 2,STAT113,Stat2,STAT2
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human STAT2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：P52630
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
