Background：This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase （PI3K）-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
仕様
Synonyms：AKT iphosphorylation enhancer,Akt phosphorylation enhancer,APE,Ccdc88a,Coiled coil domain containing 88A,Coiled coil domain containing protein 88A,Coiled-coil domain-containing protein 88A,FLJ10392,G alpha interacting vesicle associated protein,G alpha-interacting vesicle-associated protein,Galpha interacting vesicle associated protein,Girders of actin filament,Girdin,GIV,GRDN,GRDN,HkRP1,Hook related protein 1,Hook-related protein 1,KIAA1212
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：1mg/mL
Immunogen：Synthetic peptide of human CCDC88A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q3V6T2
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
