Background：The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
仕様
Synonyms：BSCL3,CAV,CAV1,CAV1,caveolae protein,22 kD,caveolin 1 alpha isoform,caveolin 1 beta isoform,Caveolin 1 caveolae protein 22kDa,Caveolin-1,Caveolin1,cell growth-inhibiting protein 32,CGL3,LCCNS,MSTP085,OTTHUMP00000025031,PPH3,VIP 21,VIP21
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human CAV1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：1000-1：5000, IHC 1：50-1：200
Swissprot：Q03135
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction, Tags ＆ Cell Markers
