Background：NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5（ARK5） is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 （PP1） complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1： phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
仕様
Synonyms：AMP activated protein kinase family member 5,AMPK related protein kinase 5,AMPK-related protein kinase 5,NUAK family SNF1 like kinase,NUAK family SNF1-like kinase 1,Nuak1,NUAK1,Omphalocele kinase 1,Probable serine/threonine protein kinase KIAA0537
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Synthetic peptide of human NUAK1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
