Background：The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase （AMPK）. AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仕様
Synonyms：5 AMP activated protein kinase alpha 1catalytic subunit,5 AMP activated protein kinase catalytic alpha 1 chain,5' AMP activated protein kinase catalytic subunit alpha 1,5'-AMP-activated protein kinase catalytic subunit alpha-1,AAPK1,AAPK1,ACACA kinase,acetyl CoA carboxylase kinase,AI194361,AI450832,AL024255,AMP -activate kinase alpha 1 subunit,AMP-activated protein kinase,catalytic,alpha -1,AMPK 1,AMPK alpha 1,AMPK alpha 1 chain,AMPK,AMPK subunit alpha-1,AMPK1,AMPKa1,AMPKalpha1,C130083N04Rik,cb116,EC 2.7.11.1,HMG CoA reductase kinase,HMGCR kinase,hormone sensitive lipase kinase,Hydroxymethylglutaryl CoA reductase kinase,im：7154392,kinase AMPK alpha1,MGC33776,MGC57364,OTTHUMP00000161795,OTTHUMP00000161796,PRKAA 1,PRKAA1,Protein kinase AMP activated alpha 1 catalytic subunit,SNF1-like protein AMPK,SNF1A,Tau protein kinase PRKAA1,wu：fa94c10
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human PRKAA1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：100-1：300
Swissprot：Q13131
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
