Background：Fructose-1,6-bisphosphate aldolase （EC 4.1.2.13） is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5％ of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
仕様
Synonyms：ALDB,ALDO B,ALDO2,ALDOB,ALDOB,Aldolase 2,Aldolase B,Aldolase B fructose bisphosphate,Aldolase2,AldolaseB,EC 4.1.2.13,Fructose bisphosphate aldolase B,Fructose-bisphosphate aldolase B,Liver type aldolase,Liver-type aldolase,MS1077
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Synthetic peptide of human ALDOB
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：50-1：200
Swissprot：P05062
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
