Background：Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex （EJC） that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仕様
Synonyms：ACIN 1,ACIN1,ACINU,Acinus,ACN,Apoptotic chromatin condensation inducer 1,Apoptotic chromatin condensation inducer in the nucleus,DKFZp667N107,fSAP152,functional spliceosome-associated protein 152,KIAA0670
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.2mg/mL
Immunogen：Synthetic peptide of human ACIN1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q9UKV3
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism
