Background：This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
仕様
Synonyms：bA525O21.1 （coagulation factor XIII,A1 polypeptide）,Coagulation factor XIII A chain,Coagulation factor XIII A1 polypeptide,Coagulation factor XIII A1 subunit,Coagulation factor XIII,A polypeptide,Coagulation factor XIIIa,F13A,F13A,F13a1,Factor XIIIA,Fibrin stabilizing factor,A subunit,Fibrinoligase,FSF,A subunit,Protein glutamine gamma glutamyltransferase A chain,Protein-glutamine gamma-glutamyltransferase A chain,TGase,Transglutaminase A chain,Transglutaminase,plasma,Transglutaminase. plasma
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.1mg/mL
Immunogen：Synthetic peptide of human F13A1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：100-1：300
Swissprot：P00488
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Tags ＆ Cell Markers
