Background：The A-kinase anchor proteins （AKAPs） are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A （PKA） and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
仕様
Synonyms：A kinase （PRKA） anchor protein （gravin） 12,A kinase Anchor Protein 12,A kinase anchor protein 250kDa,A-kinase anchor protein 12,A-kinase anchor protein 250 kDa,AKA12,AKAP 12,AKAP 250,AKAP-12,Akap12,AKAP250,DKFZp686M0430,DKFZp686O0331,FLJ20945,FLJ97621,Gercelin,Gravin,Kinase scaffold protein gravin,Myasthenia gravis autoantigen,Myasthenia gravis autoantigen gravin,OTTHUMP00000017426,OTTHUMP00000017427,Src-Suppressed C Kinase Substrate,Srcs5,SSeCKS,Tsga12
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human AKAP12
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q02952
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
