Background：Cell surface receptor for LCN2 （24p3） that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 （holo-24p3）, followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 （apo-24p3）, followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
仕様
Synonyms：24p3 receptor,24p3R,BOCT,BOIT,Brain type organic cation transporter,Brain-type organic cation transporter,hBOIT,Lipocalin-2 receptor,Neutrophil gelatinase associated lipocalin receptor,Neutrophil gelatinase-associated lipocalin receptor,NGAL receptor,NgalR,NGALR2,NGALR3,OTTHUMP00000082690,OTTHUMP00000082691,Potent brain type organic ion transporter,S22AH,Slc22a17,Solute carrier family 22 member 17,Solute carrier family 22 organic cation transporter member 17
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Synthetic peptide of human SLC22A17
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q8WUG5
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
