Background：The protein encoded by this gene is a member of the protein tyrosine phosphatase （PTP） family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：CD 148,CD148,CD148 antigen,Density enhanced phosphatase 1,Density-enhanced phosphatase 1,DEP 1,DEP-1,HPTP eta,HPTPeta,Human density enhanced phosphatase 1,Protein tyrosine phosphatase eta,Protein tyrosine phosphatase receptor type J,Protein tyrosine phosphatase receptor type J polypeptide,Protein-tyrosine phosphatase eta,Protein-tyrosine phosphatase receptor type J,PTPJ,Ptprj,PTPRJ,R PTP Eta,R-PTP-eta,R-PTP-J,Receptor type tyrosine protein phosphatase eta,Receptor-type tyrosine-protein phosphatase eta,SCC 1,SCC1,susceptibility to colon cancer 1,mouse,homolog of
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human PTPRJ
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
