Background：This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. Component of the anaphase promoting complex/cyclosome （APC/C）, a cell cycle-regulated E3 ubiquitin ligase that controls progression througHuman, Mouseitosis and the G1 phase of the cell cycle.
