Background：The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme （ACE） to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
仕様
Synonyms：Aangiotensinogen （serpin peptidase inhibitor clade A member 8）,AGT,AI265500,Alpha 1 antiproteinase antitrypsin,Ang,Ang I,Ang II,Ang III,AngII,Angiotensin I,Angiotensin II,Angiotensin III,Angiotensin-3,Angiotensinogen （PAT）,Angiotensinogen,ANGT,ANHU,ANRT,AT-2,AT-II,Des-Asp[1]-angiotensin II,FLJ92595,FLJ97926,MGC105326,PAT,Pre angiotensinogen,Serine （or cysteine） proteinase inhibitor,Serpin A8,Serpin peptidase inhibitor clade A member 8,SERPINA8
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：0.2mg/mL
Immunogen：Synthetic peptide of human AGT
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：25-1：100
Swissprot：P01019
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
