Background：TNIP3, which called LIND, that was upregulated in monocytes infected with Listeria monocytogenes. The predicted 325-amino acid protein contains 3 coiled-coil domains and is most likely localized to the nucleus. Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 （TLR4）, interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
仕様
Synonyms：A20 binding inhibitor of NF kappa B activation 3,ABIN 3,ABIN 3 beta,FLJ21162,LIND,Listeria induced,Listeria induced gene protein,TNFAIP3 interacting protein 3,TNFAIP3 interacting protein 3 beta,TNIP3,TNIP3 beta
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human TNIP3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000
Swissprot：Q96KP6
Isotype：IgG
Research Areas：Cardiovascular, Signal transduction
