Background：This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems （gemini of coiled bodies） and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
仕様
Synonyms：Component of gems 2,Gem （nuclear organelle） associated protein 2,Gem associated protein 2,GEMI2,Gemin-2,gemin2,SIP 1,SIP-1,SIP1,SIP1 delta,SIP1-delta,SMN interacting protein 1,SMN interacting protein 1 delta,SMN-interacting protein 1,Survival interacting protein 1,Survival of motor neuron protein interacting protein 1,Survival of motor neuron protein-interacting protein 1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.1mg/mL
Immunogen：Synthetic peptide of human GEMIN2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：O14893
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
