Background：PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors
仕様
Synonyms：Cancer/testis antigen 80,CT80,Hiwi like,MILI,Miwi like,Piwi like 2,Piwi-like protein 2,Piwil2,PIWL2
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human PIWIL2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q8TC59
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Stem cells
