Background：Low density lipoprotein receptor-related protein associated protein 1also known asLRPAP1orRAPis a chaperoneproteinwhich in humans is encoded by the LRPAP1gene. LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all know ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II.
仕様
Synonyms：39 kDa receptor-associated protein,A2MRAP,A2RAP,Alpha 2 macroglobulin receptor associated protein,Alpha 2 MRAP,Alpha-2-macroglobulin receptor-associated protein,Alpha-2-MRAP,AMRP,HBP44,Lipoprotein receptor associated protein,Low density lipoprotein receptor related protein associated protein 1,Low density lipoprotein receptor-related protein-associated protein 1,Low density lipoprotein related protein associated protein 1 alpha 2 macroglobulin receptor associated protein,Low density lipoprotein related protein associated protein 1,low density lipoprotein-related protein-associated protein 1 （alpha-2-macroglobulin receptor-associated protein 1）,Lrpap1,MGC138272,MRAP,MYP23,RAP
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：1mg/mL
Immunogen：Synthetic peptide of human LRPAP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：50-1：200
Swissprot：P30533
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
