Background：The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein （MAP） kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
仕様
Synonyms：CL 100,CL100,Dual Specificity Phosphatase 1,Dual specificity protein phosphatase 1,Dual specificity protein phosphatase hVH1,DUS1,DUSP 1,Dusp1,HVH1,MAP kinase phosphatase 1,Mitogen-activated protein kinase phosphatase 1,MKP-1,MKP1,Protein tyrosine phosphatase CL100,Protein-tyrosine phosphatase CL100,PTPN10,Serine/threonine specific protein phosphatase,VH1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human DUSP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
