Background：The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein （MAP） kinase superfamily （MAPK/ERK, SAPK/JNK, p38）, which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
仕様
Synonyms：C11orf81,Chromosome 11 open reading frame 81,Deubiquitinating enzyme 8,Dual Specificity Phosphatase 8,Dual specificity phosphatase M3/6,Dual specificity protein phosphatase 8,Dual specificity protein phosphatase hVH 5,Dual specificity protein phosphatase hVH-5,DUS8,DUS8,DUSP8,EC 3.1.3.16,EC 3.1.3.48,FLJ42476,FLJ42958,H1 phosphatase vaccinia virus homolog,H1 phosphatase,vaccinia virus,homolog of,HB5,hUBPy,HVH5,HVH8,M3/6,mouse,homolog of,Neuronal tyrosine threonine phosphatase 1,Serine/threonine specific protein phosphatase,Ubiquitin carboxyl terminal hydrolase 8,Ubiquitin specific processing protease 8,Ubiquitin thiolesterase 8,VH5
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human DUSP8
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
