Background：The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta （TGFB）. In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
仕様
Synonyms：OTTHUMP00000213557,OTTHUMP00000213591,OTTHUMP00000213592,OTTHUMP00000213595,SKI like,SKI like oncogene,Ski like protein,SKI like proto oncogene,Ski related oncogene,Ski related oncogene snoN,Ski related protein,Ski-like protein,Ski-related oncogene,Ski-related protein,SKIL,SKIL,SNO,SnoA,SnoI,SnoN
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human SKIL
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000, IHC 1：30-1：150
Swissprot：P12757
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
