Background：This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome （BBS） proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants.
仕様
Synonyms：5530402H04Rik,6130400H19Rik,AI414725,AW048545,BBS17,DKFZp686H2076,FLJ36386,Leucine zipper transcription factor like 1,Leucine zipper transcription factor like protein 1,Leucine zipper transcription factor-like protein 1,LZTFL 1,Lztfl1,Lztfl1 leucine zipper transcription factor-like 1,LZTL1,MGC106871,MGC108960,Putative uncharacterized protein DKFZp686H2076
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human LZTFL1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
