Background：JMJD1B （jumonji domain containing 1B）, also known as KDM3B, 5qNCA （5q Nuclear Co-Activator） or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.
仕様
Synonyms：5qNCA,C5orf7,JHDM2B,JmjC domain containing histone demethylation protein 2B,JmjC domain-containing histone demethylation protein 2B,jmjd1b,Jumonji domain containing 1B,Jumonji domain containing protein 1B,Jumonji domain-containing protein 1B,KDM3B,KDM3B,KIAA1082,Lysine （K） specific demethylase 3B,Lysine-specific demethylase 3B,NET22,Nuclear protein 5qNCA
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human KDM3B
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：1000-1：5000, IHC 1：50-1：200
Swissprot：Q7LBC6
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
