Background：This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.
仕様
Synonyms：GA45B,GADD45 Beta,Gadd45b,GADD45BETA,Growth arrest and DNA damage inducible 45 beta,Growth arrest and DNA damage inducible beta,Growth arrest and DNA damage-inducible gene GADD45,beta,Growth arrest and DNA damage-inducible protein GADD45 beta,Growth arrest and DNA-damage-inducible protein GADD45 beta,MY118,MYD118,MYD118,mouse,homolog of,Myeloid differentiation primary response gene,Myeloid differentiation primary response protein MyD118,Negative growth regulatory protein MyD118,Negative growth-regulatory protein MyD118
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Recombinant protein of human GADD45B
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：O75293
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
