Background：REDD-2 （regulated in development and DNA damage response 2）, also designated Rtp801L or DDIT4L （DNA-damage-inducible transcript 4-like）, is a 193 amino acid cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR （mammalian target of rapamycin） pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx （thioredoxin-1） expression. REDD2 expression in macrophages increases oxidized LDL （oxLDL）-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.
仕様
Synonyms：DNA damage inducible transcript 4 like,DNA damage inducible transcript 4 like protein,HIF 1 responsive protein RTP801 like,Homolog of mouse SMHS1,Protein regulated in development and DNA damage response 2,Protein regulated in development and DNA damage responses 2,REDD 2,REDD2,Regulated in development and DNA damage response 2,RTP801L
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.7mg/mL
Immunogen：Recombinant protein of human DDIT4L
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
