Background：The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA （MIM 164014）, RELB （604758）, NFKB1 （MIM 164011）, and NFKB2 （MIM 164012）. These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor
